microcrystalline cellulose msds fmc

: 9004-34-6 Date Approved: 01/31/2008 . CAS 9004-34-6. 9,LL!z We can send by Fedex, by ship or by plane according to international rules. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . << The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 2008-2023 ChemPoint. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. It is hygroscopic and insoluble in water. /Resources 2 0 R It works as a moisture sponge and permits the controlled growth of spheroids. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Validity Area. Microcrystalline Cellulose (MCC) Manufacturing Industry. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Microcrystalline Cellulose. The most. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Earth Supplied Products LLC. Request media, explore upcoming events and read our latest updates. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. Home. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. In 1964 FMC, Corporation . gwf;J(e0o|1p{R~P^);ao!%{0KD7. endobj Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . endobj It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. << 1 0 obj stream Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Chemical Formula: (C6H10O5)n 1.4. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b Battista, O. BIOACCUMULATIVE POTENTIAL Eur., JPE . The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. };khd5x=fr Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. EINECS #: 232-674-9 1.7. : 160182. B;vLZpHU%ChUyD+[ Quantity: 1 700 kgs. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. This Microcrystalline Cellulose . They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. stream It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. The typical mean particle size is 20200 m. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. (Microcrystalline Cellulose Market Pr. <> endstream Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. <> Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Microcrystalline cellulose is a commonly used excipient in the . It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Watch Now. No. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. 4. 0.25 - 0.37. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Some substance identifiers may have been claimed confidential, or may . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Catalog Number 102331. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Molecular Weight null. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. HMo@9, U Q!R/1*;` Microcrystalline Cellulose E460 MSDS 1. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. stream Manufactured by: China . Trademarks: Avicel PH-102. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Delivering efficient and robust formulations. 4 0 obj Have an order or account question? Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Microcrystalline Cellulose NF. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Created Date: 2/10/2020 8:51:41 PM . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Watch Now. 2 0 obj % Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. LOT #: Available upon request. gac74 [#B6`Wnw7 cas:9032-51-3 msds CELLULOSE PAB. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Well-recognized product that can do it all. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Meet our leadership team. It is, however, a good source of fibre. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Biologicals by FMC. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Date Approved: 05/25/2010. Micro Crystalline Cellulose. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. MCC helps in the formation of spheres because of its . : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. cas:9000-11-7 msds Carboxymethyl cellulose. %PDF-1.3 INCI. ). The cellulose molecule is formed through repeated condensation of cellobiose units. Buy Chemicals. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. endobj Van Veen, G.K. Bolhuis, Y.S. A family of polysaccharide products that allow distinctive drug delivery solutions. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Product Name: Microcrystalline Cellulose 1.2. 0.25 - 0.37. 6 1. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Microcrystalline Cellulose / Avicel PH-102. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. No. l~5C Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Document(s): certificate data msds. 3 0 obj Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. FMC Corporation. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. stream The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Product Name Cellulose microcrystalline. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. If breathing is difficult or if . It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? It is also inert and biocompatible. Product Name: Microcrystalline Cellulose E460 1.2. (&E. There have always been two different points of view for the liquidity of MCC. These, in turn, are assembled into fibrils in the cell wall. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . >> Quick Links. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Page 1 of 8. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL It is available in different grades and particle sizes. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Avicel PC 611 (FMC Biopolymer) Supplied by. endobj X\o^ >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ CoA. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Apply today! SUBSTANCE IDENTIFICATION 1.1. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. . Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Millipore. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . However, if handling bulk powders, observance of appropriate safeguards is recommended. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. However, consumption of large quantities of the material may have a laxative effect. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Superior Performance: Provides excellent water uptake and rapid swelling . There may be more fiber in your food than you realized. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Product and Company Identification . SUBSTANCE IDENTIFICATION 1.1. CAS #: 9004-34-6 MSDS Ref. xv}O2' H~KEe9>G/,:9\i

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